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دانلود کتابPoorly Soluble Drugs: Dissolution and Drug Release (Pan Stanford Series on Pharmaceutical Analysis) 1st Edition

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خرید کتاب Poorly Soluble Drugs: Dissolution and Drug Release (Pan Stanford Series on Pharmaceutical Analysis) 1st Edition

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Poorly Soluble Drugs: Dissolution and Drug Release (Pan Stanford Series on Pharmaceutical Analysis) 1st Edition
by Gregory K. Webster (Author), Robert G. Bell (Author), J. Derek Jackson (Author)

Series: Pan Stanford Series on Pharmaceutical Analysis (Book 1)

Hardcover: 728 pages
Publisher: Pan Stanford; 1 edition (December 16, 2016)
Language: English
ISBN-10: 9814745456
ISBN-13: 978-9814745451

Price: 20$

This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development.

Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.

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