دانلود کتابReagents for Silicon-Mediated Organic Synthesis 1st Edition
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خرید کتاب Reagents for Silicon-Mediated Organic Synthesis 1st Edition
Reagents for Silicon-Mediated Organic Synthesis 1st Edition
by Philip L. Fuchs (Editor)
Hardcover: 854 pages
Publisher: Wiley; 1 edition (November 7, 2011)
Over the last three decades the importance of organosiliconchemistry has greatly increased because it has opened a number ofnew synthetic strategies. Silicon reagents are usually low-cost,versatile and allow a wide range of reactions. This is the firstHandbook to compile essential Silicon containing reagents and makesuse of the leading reagent database e-EROS. Another hotvolume in the series Handbooks of Reagents for OrganicSynthesis, this is a must-have resource for all syntheticchemists working in drug development and medicinal chemistry.For the selection the Editor focussed on three key syntheticapproaches with the greatest impact:
1. Use of silicon as a ‘temporary tether’ by unifying a reactivepair of functional groups and taking advantage of theirtemplate-biased intramolecular cyclization.
2. The specific use of the silane functionality as a heterot-butyl group, often colloquially referred to as the use ofsilicon as a ‘fat proton’.
3. The use of the Brook rearrangement as an ‘anion relaystratagem’.
A new feature in this Handbook is the reagent finder, analphabetically organized lookup table arranged by organicfunctionality and specific structure of the silicon atom to whichit is bound.