خرید ایبوک Textbook of Pediatric Rheumatology

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خرید کتاب Textbook of Pediatric Rheumatology 9th Edition

دانلود رایگان کتاب Textbook of Pediatric Rheumatology 9th Edition

*Selected for 2026 Doody’s Core Titles in Rheumatology**

This core textbook discusses the presentation and pathophysiology, differential diagnosis, management, and prognosis for a comprehensive range of pediatric rheumatic conditions. Global leaders in the field provide evidence-based guidance highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies the investigation, recognition, and management of rheumatic diseases in childhood and adolescence.

An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

Addresses the full spectrum of rheumatic diseases, from typical juvenile idiopathic arthritis to rare and newly recognized syndromes, providing practical guidance on diagnosis, outcome measurement, and management―including both pharmacologic and multidisciplinary strategies

Covers state-of-the-art advances in pediatric rheumatology, including genomic and multi-omics approaches, the latest targeted therapies, modern imaging, and evolving concepts in autoinflammation and immune deficiency

Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible, and provides updates of laboratory investigations, imaging techniques, physical and occupational therapy, approach to chronic musculoskeletal pain syndromes, and much more

Features reviews of the complex symptoms, signs, and laboratory abnormalities that characterize these disorders

Shares the knowledge and expertise of two new editors, Drs. Jonathan Akikusa and Hermine Brunner, and 38 new contributing authors who are international leaders in the field of pediatric rheumatology

دانلود ایبوک درسی روماتولوژی کودکان، ویرایش نهم

انتخاب شده برای عناوین اصلی دودی در سال ۲۰۲۶ در زمینه روماتولوژی**

این کتاب درسی اصلی، به بررسی تظاهرات و پاتوفیزیولوژی، تشخیص افتراقی، مدیریت و پیش‌آگهی طیف گسترده‌ای از بیماری‌های روماتیسمی کودکان می‌پردازد. رهبران جهانی در این زمینه، راهنمایی‌های مبتنی بر شواهد را با تصاویر رنگی فوق‌العاده برجسته می‌کنند که درک کاملی از علمی را که زیربنای بررسی، تشخیص و مدیریت بیماری‌های روماتیسمی در دوران کودکی و نوجوانی است، تسهیل می‌کند. طیف کاملی از بیماری‌های روماتیسمی، از آرتریت ایدیوپاتیک نوجوانان معمولی گرفته تا سندرم‌های نادر و تازه شناخته شده، را مورد بررسی قرار می‌دهد و راهنمایی‌های عملی در مورد تشخیص، اندازه‌گیری پیامد و مدیریت – از جمله استراتژی‌های دارویی و چند رشته‌ای – ارائه می‌دهد.

پیشرفت‌های پیشرفته در روماتولوژی کودکان، از جمله رویکردهای ژنومی و چند اُمیک، جدیدترین درمان‌های هدفمند، تصویربرداری مدرن و مفاهیم در حال تکامل در خودالتهابی و نقص ایمنی را پوشش می‌دهد.

تغییرات در تشخیص، پایش و مدیریت را که پیشرفت‌های اخیر ممکن ساخته‌اند، منعکس می‌کند و به‌روزرسانی‌هایی از تحقیقات آزمایشگاهی، تکنیک‌های تصویربرداری، فیزیوتراپی و کاردرمانی، رویکرد به سندرم‌های درد مزمن اسکلتی-عضلانی و موارد دیگر را ارائه می‌دهد.

بررسی علائم، نشانه‌ها و ناهنجاری‌های آزمایشگاهی پیچیده‌ای که این اختلالات را مشخص می‌کنند، ارائه می‌دهد.

دانش و تخصص دو ویراستار جدید، دکتر جاناتان آکیکوسا و هرمین برونر، و ۳۸ نویسنده جدید که رهبران بین‌المللی در زمینه روماتولوژی کودکان هستند را به اشتراک می‌گذارد.

یک نسخه الکترونیکی با خرید کتاب همراه است. این کتاب الکترونیکی به شما امکان می‌دهد به تمام متن، شکل‌ها و منابع دسترسی داشته باشید، همچنین می‌توانید محتوا را جستجو کنید، آن را شخصی‌سازی کنید، یادداشت‌برداری و هایلایت کنید و محتوا را با صدای بلند بخوانید.

فهرست مطالب کتاب نلسون روماتولوژی ویرایش نهم

1. Cover image
2. Title page
3. Copyright
4. Dedication
5. Contributors
6. Preface
7. Contents
8. SECTION A Introduction
9. 1 Evolution of Pediatric Rheumatology
10. Introduction
11. The Emergence of Pediatric Rheumatology Around the World
12. Current Global Challenges
13. Epidemiology and the Huge Burden of Disease
14. Delay in Diagnosis and Access to Specialist Care
15. The Cost of Care
16. Challenges Related to Comorbidities
17. Strategies to Improve Outcomes
18. Enhancement and Expanding Research Capacity
19. Key References
20. Online References
21. Section B Basic Concepts
22. 2 Structure and Function
23. Introduction
24. The Skeleton
25. Tendons
26. Ligaments and Fascia
27. Entheses
28. Bursae
29. Skeletal Muscle
30. Key References
31. Online References
32. 3 Innate Immunity
33. Cells of Innate Immunity
34. The Inflammatory Response
35. When Defective Regulation of Innate Immunity Leads to Rheumatic Disease
36. Key References
37. Online References
38. 4 Adaptive Immunity
39. Introduction to Adaptive Immunity
40. T Cells
41. B Cells
42. Antigen Presentation
43. Conclusions
44. Key References
45. Online References
46. 5 Multiomics Approaches to Rheumatic Disease
47. Introduction
48. Overview of Omics
49. Analysis Approach
50. Examples of Omics and Their Applications in Pediatric Rheumatology
51. Challenges and Future of Omics
52. Key References
53. Online References
54. 6 Genetics and Pediatric Rheumatic Diseases
55. Introduction
56. Genes, Variation and the Human Genome Sequence in Biomedical Research
57. Techniques for Genetic and Genomic Investigation
58. Approaches for Investigating Monogenic Pediatric Rheumatic Disease
59. Approaches for Investigating Polygenic Pediatric Rheumatic Disease
60. Candidate Gene Studies in Pediatric Rheumatology
61. Transmission Disequilibrium Testing
62. Genome-Wide Association Studies
63. Genome Editing
64. Key References
65. Online References
66. Section C Clinical Research in Pediatric Rheumatology
67. 7 Understanding Clinical Investigations
68. Truth, Levels of Evidence and Evidence-Based Medicine
69. Types of Clinical Investigations
70. Basic Concepts
71. Study Design
72. Describing Data
73. Paradigms of Inference
74. Concepts and Terminology for Communicating Study Results
75. Basic Tests of Association
76. Advanced Data Analyses
77. Assessing and Interpreting Results
78. Assessing the Quality of Clinical Investigations
79. Key References
80. Online References
81. 8 Clinical Outcome Measures in Pediatric Rheumatic Diseases
82. Introduction
83. Juvenile Idiopathic Arthritis
84. Systemic Lupus Erythematosus (SLE)
85. Juvenile Dermatomyositis
86. The 2016 ACR/EULAR Criteria for Clinical Response in Juvenile Dermatomyositis
87. Scleroderma
88. Systemic Vasculitis
89. Parent- and Child-Reported Outcomes
90. Conclusions
91. Key References
92. Online References
93. Section D Clinical Investigations in Pediatric Rheumatology
94. 9 Laboratory Investigations
95. INTRODUCTION
96. LABORATORY METHODS
97. TESTS
98. OTHER LABORATORY INVESTIGATIONS
99. SYNOVIAL FLUID
100. URINALYSIS
101. GENETIC ASSESSMENT OF RHEUMATIC DISEASES
102. THE FUTURE
103. Key References
104. Online References
105. 10 Imaging in Pediatric Rheumatic Diseases
106. Introduction
107. Key Imaging Modalities
108. Juvenile Idiopathic Arthritis (See Chapters 16–21)
109. Vasculitis
110. Idiopathic Inflammatory Myopathy (see also Chapter 30)
111. Inflammatory Lung Conditions
112. Infectious and Other Inflammatory Conditions
113. Other Conditions
114. Key References
115. Online References
116. Section E Management of Rheumatic Diseases in Children
117. 11 Principles in the Management of Patients With Rheumatic Diseases
118. Introduction
119. General Approach to Management
120. Specific Management Considerations
121. Summary
122. Key References
123. Online References
124. 12 Therapeutics: Nonbiologics
125. INTRODUCTION
126. CONCEPTS IN PHARMACOLOGY
127. ANTIRHEUMATIC DRUGS
128. Therapeutics for Amplified Pain
129. Key References
130. Online References
131. 13 Therapeutics: Biologics and Targeted Small Molecules
132. INTRODUCTION
133. GENERAL CONSIDERATIONS
134. INTRAVENOUS IMMUNOGLOBULIN
135. BIOLOGICS INHIBITING T-CELL CO-STIMULATION
136. B-CELL TARGETED BIOLOGICS
137. INTERFERENCE WITH CYTOKINES
138. Key References
139. Online References
140. 14 Physical and Occupational Therapy
141. Introduction
142. Prevalence of Joint and Muscle Issues
143. Assessment of Joint Range of Motion and Muscle Flexibility
144. Assessment of Muscle Function and Muscle Strength
145. Improving Joint and Muscle Health
146. Joint and Muscle Exercise
147. Motor Development and Motor Performance
148. Motor Learning, Normalization, Adaptation, and Compensation Strategies
149. Early Motor Milestones, Motor Proficiency at School Age, Physical Literacy, Sports, and Athletic Skills at Adolescence
150. Physical Activity Level and Exercise Tolerance
151. Occupational Participation
152. Psychosocial Supports and Chronic Health Management
153. Pain Management
154. Fatigue Management
155. Sleep Routines and Hygiene
156. Effects of Uveitis on Function
157. Long-Term Considerations: Supporting those with ongoing active disease or residual damage
158. Additional Aspects of Health
159. Summary
160. Key References
161. Online References
162. 15 The Assessment and Management of Osteoporosis in Childhood
163. INTRODUCTION
164. PHYSIOLOGY OF THE DEVELOPING SKELETON
165. OSTEOPOROSIS IN PEDIATRIC RHEUMATIC DISORDERS: CLINICAL MANIFESTATIONS AND RISK FACTORS
166. DIAGNOSIS AND MONITORING OF OSTEOPOROSIS IN PEDIATRIC RHEUMATIC DISORDERS
167. IMPACT OF MEDICAL THERAPIES ON SKELETAL HEALTH IN CHILDHOOD
168. FUTURE DIRECTIONS
169. Key References
170. Online References
171. Section F Juvenile Idiopathic Arthritis and Related Conditions
172. 16 Juvenile Idiopathic Arthritis: Classification and Basic Concepts
173. Historical Aspects
174. Classifications of Chronic Childhood Arthritis
175. Epidemiology
176. Genetic Associations
177. Clinical Manifestations of JIA
178. Pathology
179. Imaging
180. Burden of Disease
181. Key References
182. Online References
183. 17 Systemic Juvenile Idiopathic Arthritis
184. Introduction
185. Epidemiology
186. Etiology and Pathogenesis
187. Clinical Manifestations and Classification
188. Diagnosis and Differential Diagnosis
189. Pathology
190. Laboratory Examinations
191. Radiological Examination
192. Treatment
193. Key References
194. Online References
195. 18 Polyarticular Juvenile Idiopathic Arthritis
196. Introduction
197. Rheumatoid Factor–Negative Polyarticular JIA
198. RHEUMATOID FACTOR POSITIVE POLYARTHRITIS
199. Key References
200. Online References
201. 19 Oligoarticular Juvenile Idiopathic Arthritis
202. Definition/Introduction
203. Historical Background
204. Demographics and Epidemiology
205. Incidence and Prevalence
206. Age at Onset and Sex Ratio
207. Etiology and Pathogenesis
208. Clinical Manifestations
209. Complications
210. Diagnosis and Differential Diagnosis
211. Treatment
212. Key References
213. Online References
214. 20 Enthesitis-Related Juvenile Idiopathic Arthritis
215. Definition and Classification
216. Demographics and Epidemiology
217. Etiology
218. Pathogenic Mechanisms
219. Clinical Manifestations
220. Pathology
221. Differential Diagnosis
222. Laboratory Examination
223. Imaging
224. Treatment
225. Application of Adult Guidelines to ERA/JSpA
226. Course of the Disease and Prognosis
227. Key References
228. Online References
229. 21 Psoriatic Juvenile Idiopathic Arthritis
230. DEFINITION AND CLASSIFICATION
231. EPIDEMIOLOGY
232. ETIOLOGY, PATHOLOGY, AND PATHOGENESIS
233. CLINICAL MANIFESTATIONS
234. Extraarticular manifestations
235. LABORATORY EXAMINATION
236. RADIOLOGIC EXAMINATION
237. TREATMENT
238. Course and prognosis
239. Key References
240. Online References
241. 22 Uveitis in Juvenile Idiopathic Arthritis
242. Classification of Uveitis
243. Uveitis in Juvenile Idiopathic Arthritis
244. Differential Diagnosis
245. Laboratory Examination
246. Management
247. Disease Course and Prognosis
248. Key References
249. Online References
250. Section G Arthritis Related to Infection
251. 23 Acute Rheumatic Fever and Post-streptococcal Arthritis
252. ACUTE RHEUMATIC FEVER
253. Introduction
254. Epidemiology
255. Etiology and Pathogenesis
256. Clinical Manifestations
257. Pathology
258. Diagnosis: Revised 2015 Jones Criteria
259. Differential Diagnosis
260. Treatment
261. Monitoring
262. Course of the Disease and Prognosis
263. Post-streptococcal Reactive Arthritis
264. Definition and Classification
265. Epidemiology
266. Etiology and Pathogenesis
267. Clinical Manifestations
268. Diagnosis and Differential Diagnosis
269. Treatment
270. Course of the Disease and Prognosis
271. Acknowledgment
272. Key References
273. Online References
274. 24 Reactive Arthritis
275. Reactive Arthritis Following Enteric, Genitourinary and Respiratory Infections
276. Classification and Diagnostic Criteria
277. Epidemiology
278. Genetic Background
279. Pathogenesis
280. Clinical Manifestations
281. Laboratory Examination
282. Imaging Studies
283. Differential Diagnosis
284. Treatment
285. Course of the Disease and Prognosis
286. Acknowledgment
287. Key References
288. Online References
289. 25 Lyme Disease
290. Epidemiology
291. Etiology and Pathogenesis
292. Clinical Manifestations
293. Diagnosis
294. Treatment
295. Outcomes
296. Special Considerations
297. Coinfections
298. Prevention
299. KEY References
300. Online References
301. 26 Infectious Arthritis and Osteomyelitis
302. INTRODUCTION
303. SEPTIC ARTHRITIS
304. COURSE AND PROGNOSIS OF SEPTIC ARTHRITIS
305. ARTHRITIS CAUSED BY VIRUSES
306. DNA
307. ARTHRITIS ASSOCIATED WITH OTHER ORGANISMS
308. ARTHRITIS AND SYSTEMIC BACTERIAL INFECTIONS
309. OSTEOMYELITIS
310. KEY REFERENCES
311. Online References
312. Section H Autoimmune and Inflammatory Connective Tissue Disorders and Related Syndromes
313. 27 Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease
314. Systemic Lupus Erythematosus
315. Epidemiology
316. Etiology and Pathogenesis
317. Clinical Disease Presentation
318. General Laboratory Evaluation
319. Approach to the Child With cSLE
320. Outcome
321. Summary
322. Mixed Connective Tissue Disease
323. Undifferentiated Connective Tissue Disease and Overlap Syndromes
324. Key References
325. Online References
326. 28 Neonatal Lupus Erythematosus
327. INTRODUCTION
328. HISTORIC BACKGROUND
329. CLASSIFICATION CRITERIA
330. DEMOGRAPHICS AND EPIDEMIOLOGY
331. ETIOLOGY
332. GENETICS
333. PATHOGENESIS
334. CLINICAL MANIFESTATIONS
335. COMPLICATIONS
336. DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
337. PATHOLOGY
338. APPROACH TO THE FETUS/CHILD EXPOSED TO MATERNAL ANTI-Ro/La ANTIBODIES
339. TREATMENT
340. PREVENTION
341. LONG-TERM RISK OF AUTOIMMUNE DISEASE
342. KEY REFERENCES
343. Online References
344. 29 Antiphospholipid Syndrome
345. DEFINITION AND CLASSIFICATION
346. EPIDEMIOLOGY
347. ETIOLOGY AND PATHOGENESIS
348. GENETIC BACKGROUND
349. CLINICAL MANIFESTATIONS
350. PATHOLOGY
351. DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
352. LABORATORY EXAMINATION
353. RADIOLOGIC EXAMINATION
354. TREATMENT
355. COURSE OF THE DISEASE AND PROGNOSIS
356. Key References
357. Online References
358. 30 Juvenile Dermatomyositis and Other Inflammatory Muscle Diseases
359. Epidemiology
360. Etiology and Pathogenesis
361. Clinical Manifestations
362. Classification and Diagnostic Criteria
363. Laboratory Examination/Investigations
364. Differential Diagnosis
365. Treatment
366. Assessment of Disease Activity and Response to Treatment
367. Course of the Disease and Prognosis
368. Complications
369. Key References
370. Online References
371. 31 Juvenile Systemic Sclerosis
372. INTRODUCTION
373. DEMOGRAPHICS AND EPIDEMIOLOGY
374. ETIOLOGY AND PATHOGENESIS
375. DIAGNOSIS AND CLASSIFICATION OF JUVENILE SYSTEMIC SCLEROSIS
376. CLINICAL FEATURES
377. Overall Disease Monitoring
378. PATIENT-REPORTED OUTCOMES
379. DIFFERENTIAL DIAGNOSIS AND MIMICS OF JUVENILE SYSTEMIC SCLEROSIS
380. JUVENILE SYSTEMIC SCLEROSIS CARE AND TREATMENT
381. PROGNOSIS
382. The Future of Treatment in Pediatric Systemic Sclerosis
383. Key References
384. Online References
385. 32 Localized Scleroderma and Eosinophilic Fasciitis
386. Historical Review
387. Definition and Classification
388. Epidemiology
389. Etiology and Pathogenesis
390. Clinical Manifestations
391. Pathology
392. Differential Diagnosis
393. Laboratory Examination
394. Treatment of Localized Scleroderma
395. Course of the Disease and Prognosis
396. Summary
397. Key References
398. Online References
399. 33 Sjögren Disease and Immunoglobulin-G4–Related Disease
400. Sjögren Disease
401. Definition/Introduction
402. Historical background and nomenclature
403. Classification (criteria)
404. Demographics and Epidemiology
405. Etiology and pathogenesis
406. Clinical manifestations
407. Complications
408. Diagnosis and differential diagnosis
409. Pathology
410. Laboratory examination
411. Radiologic examination
412. Outcome Measures
413. Management
414. Prognosis and Outcome
415. IgG4-Related Diseases
416. Key References
417. Online References
418. 34 Raynaud Phenomena and Vasomotor Syndromes
419. RAYNAUD PHENOMENA
420. OTHER VASOMOTOR SYNDROMES
421. Summary and Future Directions
422. Key References
423. Online References
424. 35 Inflammatory Central Nervous System Disorders
425. General Approach to Inflammatory Brain Disorders
426. Overview of Diagnostic Tools Utilized in Inflammatory Brain Disorders
427. Specific Inflammatory Brain Conditions
428. Immune Dysregulation/Autoinflammatory CNS Disorders
429. Summary
430. Key References
431. Online References
432. Section I Vasculitis
433. 36 Vasculitis and Its Classification
434. Vessel Structure and Function
435. Classification
436. Evaluation of Vasculitis
437. Epidemiology
438. General Clinical Aspects of Vasculitis
439. KEY REFERENCES
440. Online References
441. 37 Takayasu Arteritis
442. INTRODUCTION
443. DEFINITION AND CLASSIFICATION CRITERIA
444. EPIDEMIOLOGY
445. GENETIC CONTRIBUTIONS
446. ETIOLOGY AND PATHOGENESIS
447. Key References
448. References
449. 38 Polyarteritis Nodosa
450. Introduction
451. Polyarteritis Nodosa (Systemic)
452. Cutaneous Polyarteritis Nodosa
453. Monogenic Autoinflammatory Conditions Mimicking PAN
454. Summary
455. Key References
456. Online References
457. 39 Kawasaki Disease
458. Historical Background
459. Definition and Diagnostic Criteria
460. Epidemiology
461. Etiology and Pathogenesis
462. Clinical Manifestations
463. Differential Diagnosis
464. Pathology
465. Laboratory Evaluation
466. Treatment
467. Monitoring Cardiac Status
468. Disease Course and Prognosis
469. Key References
470. Online References
471. 40 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
472. Introduction
473. Antineutrophil Cytoplasmic Antibodies
474. Granulomatosis With Polyangiitis
475. Disease Measurement Tools
476. Clinical Course and Outcome
477. Microscopic Polyangiitis
478. Eosinophilic Granulomatosis with Polyangiitis
479. Key References
480. Online References
481. 41 Immune Complex Small-Vessel Vasculitis: IgA Vasculitis and Hypersensitivity Vasculitis
482. IgA Vasculitis (Henoch-Schönlein Purpura)
483. Infantile Acute Hemorrhagic Edema
484. IgAV with an onset in adulthood
485. Hypersensitivity Vasculitis
486. Key References
487. Online References
488. 42 Behcet Syndrome and Its Mimics
489. Introduction
490. Classification and diagnostic criteria
491. Clinical Manifestations
492. Pathology
493. Laboratory investigations
494. Imaging
495. Differential diagnosis
496. Treatment
497. Outcome measures
498. Course of Disease and Prognosis
499. Key References
500. Online References
501. 43 Central Nervous System Vasculitis
502. Introduction
503. Primary Angiitis of the CNS
504. Differential diagnosis
505. Workup-suspected CNS vasculitis patient
506. Treatment cPACNS
507. Outcome
508. Acknowledgments
509. Key References
510. Online References
511. 44 Other Vasculitides
512. Cogan Syndrome
513. Immune Complex Small Vessel Vasculitis
514. Vasculitis Associated With Systemic Disease
515. Vasculitis-Associated With Probable Etiology
516. Other Vasculitides, Vasculopathies
517. Mimics of Vasculitis
518. Key References
519. Online References
520. Section J Immune System Dysfunction, Autoinflammation, and Immune Deficiency
521. 45 Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases
522. Introduction
523. Heterogeneity in the Genetic Basis of Systemic Autoinflammatory Diseases
524. Autoinflammatory Disorders Affecting Different Immune Pathways
525. Defects in Global Intracellular Mechanisms
526. Other Inborn Error of Immunity With Autoinflammatory Manifestations
527. Somatic Mosaicism Causing SAID
528. Autoinflammatory Disorders of Unknown Genetic Cause
529. The Future of Autoinflammatory Diseases
530. Key References
531. Online References
532. 46 Autoinflammatory Bone Diseases
533. Autoinflammatory Bone Diseases
534. Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis
535. Genetic Autoinflammatory Syndromes With Bone Inflammation
536. Summary
537. Key References
538. Online References
539. 47 Blau Syndrome, Sarcoidosis, and Related Systemic Granulomatous Diseases
540. Epidemiology
541. Etiology and Pathogenesis
542. Pathology
543. Clinical Features
544. Diagnosis
545. Pathology
546. Genetic Testing
547. Differential Diagnosis
548. Prognosis
549. Treatment
550. Key References
551. Online References
552. 48 Macrophage Activation Syndrome
553. Definition
554. Epidemiology
555. Triggers
556. Genetic Background
557. Pathophysiology
558. Clinical Features
559. Tissue Histology
560. Diagnosis
561. Differential Diagnosis
562. Treatment
563. Prognosis
564. KEY REFERENCES
565. ONLINE References:
566. 49 Inborn Errors of Immunity and Rheumatic Disease
567. Introduction
568. Infections Can Suggest an IEI Disorder
569. Complex, Multiorgan Autoimmune/Autoinflammatory Phenotypes Associated With Defects in Key Immune Cell Signaling Pathways
570. Arthritis and Inflammatory Arthropathy
571. SLE, SLE-Like IEI Disorders, and Vasculitis/Vasculopathy
572. Somatic (Acquired) Mutations—IEI Phenocopies
573. Diagnostic Evaluation of Suspected IEI Disorders
574. Summary
575. Key References
576. Online References
577. Section K Musculoskeletal Manifestations of Systemic Disorders
578. 50 Malignancies and Nonmalignant Musculoskeletal Conditions That May Mimic Rheumatic Disease
579. Introduction
580. Malignancies of Nonmusculoskeletal Origin
581. Malignant musculoskeletal and soft tissue tumors
582. Benign musculoskeletal and soft tissue tumors
583. Key References
584. Online References
585. 51 Musculoskeletal Manifestations of Inflammatory Bowel Disease
586. Definition and Classification
587. Epidemiology
588. Etiology and Pathogenesis
589. Novel Omics Technologies
590. Clinical Manifestations
591. Diagnosis and Differential Diagnosis of Peripheral and Axial Arthropathies
592. Other Rheumatic Manifestations in IBD
593. IBD Diagnostic Clues
594. Treatment and Disease Course
595. Summary
596. Key References
597. Online References
598. 52 Musculoskeletal Manifestations of Systemic Disease
599. Introduction
600. Disorders Related to Vitamin Deficiency or Excess
601. Disorders Related to Environmental Factors
602. Metabolic Diseases
603. Hematological Disorders
604. Endocrine and Exocrine Glands
605. Cystic Fibrosis
606. Celiac Disease
607. Hyperostosis
608. Key References
609. Online References
610. Section L Non-Inflammatory Musculoskeletal Conditions and Pain Syndromes
611. 53 Primary Disorders of Connective Tissue
612. Introduction
613. Skeletal Dysplasias
614. Patient Evaluation for Skeletal Dysplasias
615. Types of Skeletal Dysplasias
616. Syndromes Associated With Joint Hypermobility
617. Syndromes Associated With Joint Hypomobility
618. Disorders That May Mimic Arthritis
619. Disorders Characterized by Lytic Bone Lesions
620. Conclusions
621. Key References
622. Online References
623. 54 Localized Musculoskeletal Pain
624. Introduction
625. Pain Associated With Hypermobility
626. Common Overuse Injuries
627. Hip and Pelvis
628. Developmental Conditions
629. Miscellaneous
630. Key References
631. Online References
632. 55 Primary and Secondary Chronic Musculoskeletal Pain Syndromes
633. Introduction
634. Definition of Chronic Musculoskeletal Pain
635. Epidemiology and Known Risk Factors
636. Etiology and pathogenesis of chronic MSK pain syndromes
637. Biological factors
638. Social Factors
639. Physical Aspects
640. Clinical Manifestations
641. Specific Conditions
642. Joint Laxity
643. Neurodiversity
644. The Impact of Chronic Musculoskeletal Pain on the Child and Family
645. Communication About Pain
646. General Assessment of MSK Pain in Children
647. Treatment and Rehabilitation Pathways
648. Addressing Chronic Regional Pain Syndrome
649. Intensive Multidisciplinary Pain Programs
650. Key References
651. Online References
652. Index

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